STRUCTURAL REQUIREMENTS FOR LATHYROGENIC AGENTS
نویسندگان
چکیده
منابع مشابه
Structural Requirements for Lathyrogenic Agents
Using the chick embryo assay system, a series of organic compounds was tested for lathyrogenic activity; lathyrogenic compounds were shown to fall into 4 groups-nitriles, ureides, and 2 new groups-hydrazides and hydrazines, forming a spectrum of diminishing potency in their ability to produce solubility of collagen and skeletal deformities. Pyridoxal was seen to reverse to a great degree the ef...
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The effects of lathyrogenic agents in vivo and in vitro are described, in respect to some biochemical indices of cartilage metabolism. Lathyrogenic agents in vivo inhibited the incorporation of radiosulfate into rat epiphyseal cartilage and the isolated chondroitin sulfate. No significant changes in hydroxyproline or hexosamine content of epiphyseal cartilage were found, but there was a marked ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1961
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.114.3.295